Iron transport proteins: Gateways of cellular and systemic iron homeostasis
نویسندگان
چکیده
منابع مشابه
Systemic iron homeostasis.
The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron from macrophages, and the release of stored iron from hepatocytes. Because iron losses are comparatively very small, iron absorption and its regulation by hepcidin and ferroportin determine total body iron...
متن کاملMacrophages and systemic iron homeostasis.
As a principal aspect of their scavenging function, splenic and hepatic macrophages phagocytize and degrade senescent and damaged erythrocytes to recover iron, mainly for the production of hemoglobin in new erythrocytes but also for other carriers and enzymes requiring iron. Splenic red pulp macrophages are specialized for iron recycling with increased expression of proteins for the uptake of h...
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Iron is an essential element in our daily diet. Most iron is required for the de novo synthesis of red blood cells, where it plays a critical role in oxygen binding to hemoglobin. Thus, iron deficiency causes anemia, a major public health burden worldwide. On the other extreme, iron accumulation in critical organs such as liver, heart, and pancreas causes organ dysfunction due to the generation...
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Iron-sulfur (Fe-S) proteins contain prosthetic groups consisting of two or more iron atoms bridged by sulfur ligands, which facilitate multiple functions, including redox activity, enzymatic function, and maintenance of structural integrity. More than 20 proteins are involved in the biosynthesis of iron-sulfur clusters in eukaryotes. Defective Fe-S cluster synthesis not only affects activities ...
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1 Dipartimento di Scienze Agrarie e Ambientali-Produzione, Territorio e Agroenergia, Università degli Studi di Milano, Milano, Italy 2 Center for Sustainable Resource Sciences, RIKEN Yokohama campus, RIKEN, Yokohama, Japan 3 Department Biology I-Plant Biochemistry and Physiology, Ludwig-Maximilians-University Munich, Munich, Germany 4 Biochimie and Physiologie Moléculaire des Plantes, Centre Na...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2017
ISSN: 0021-9258
DOI: 10.1074/jbc.r117.786632